Glass bottle sealing test method and standard basis

The assurance of sterility of food and pharmaceutical products prior to use is a requirement for Food and Drug Administration testing.

Therefore, there must be validation and monitoring of glass vial integrity to ensure that food and drug products are free from microbial contamination during the entire life cycle of production, quality control transportation and storage, and even product expiration.

In this paper, we will discuss the sealing test methods for glass bottles.

As we all know, each production enterprise has its own internal quality control standards, but there is no complete seal leakage detection program and specific details, this paper uses the company's production of glass bottle sealing leak detector to explore the sealing test method of glass bottles, as well as the technical parameters of the testing instrument, technical characteristics.

Glass bottle leakage tester Glass bottle sealing test instrument

Introduction to the sealing test method of glass vials and the basis of the standard

The national standard for pharmaceutical packaging materials on the packaging container sealing test requirements, the glass bottle sealing test method is divided into positive pressure method, negative pressure method and vacuum attenuation method, this paper mainly introduces the positive pressure method, Jinan Zhongtai Electromechanical Equipment Co., Ltd. research and development of the production of the glass bottle leakage tester LSST-01 using positive pressure test principle, with user hierarchical management rights, equipped with micro-printers and a large touch-screen display.

Glass bottle leakage tester LSST-01 detects the sealing performance of glass bottles:

1. First of all, carry out the installation and debugging work, install the vacuum cylinder on the base, carry out the preliminary debugging, open the tester button switch, select the appropriate air pressure.

2. Fill the vacuum chamber (cylinder) with water, pay attention to the location of the water, do not overflow after putting the specimen.

3. Cover the sealing cover of the plexiglass cylinder, rotate the switch on the tester to the open position, and adjust the control knob of the tester, first determine whether the knob is locked (i.e., in the pressed state), if locked, the adjustment needs to be slightly forceful to pull up the knob upward, and then rotate the adjustment, and observe the vacuum pressure gauge, the pressure will be adjusted to the value you need. After adjusting to the required stable pressure, press the knob down to fix the position to prevent accidental collision and misoperation, which will lead to the change of vacuum degree in the vacuum cylinder and affect the test results.

4. Observe whether there is any continuous bubble overflow, and check the number shown on the tester display through the pressure gauge.

5. End the test of glass bottle leakage tester, pour out the water and close the tester switch.